AEME possesses greater neurotoxic potential than cocaine and an additive effect when they are combined. The smoke of crack cocaine contains cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). 8 Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Av.7 Institute of Physical Activity Sciences and Sports, Post-Graduate Program in Human Movement Sciences, Cruzeiro do Sul University, São Paulo, Brazil.6 Criminalistic Institute of São Paulo, Rua Moncorvo Filho, 410, 05507-060, São Paulo/SP, Brazil.5 Laboratory of Pharmacology, Butantan Institute, Av.4 Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, 2201 West End Avenue, 1205 Light Hall, 37232-0697, Nashville/TN, USA.3 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. 2 Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, 1° andar, 09913-030, Diadema/SP, Brazil.1 Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av.
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